Changing gut bacteria during the development of Alzheimer's in three mouse models

Approximately 55 million individuals worldwide are affected by Alzheimer's disease (AD), a progressive neurodegenerative disorder.

• AD is characterized by cognitive impairment and irreversible neuronal degeneration.
• The pathogenic mechanisms of AD are not fully understood despite extensive research.
• There is a lack of effective therapeutic strategies for preventing or delaying AD progression.
• Emerging evidence indicates that the microbiota-gut-brain axis may significantly influence neurodegenerative diseases, including AD.
• The changes in gut microbiota during AD progression in various transgenic mouse models are not well characterized.

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