Gut microbiota and metabolic syndrome

Gut microbiota may play a significant role in the pathogenesis of metabolic syndrome.

• Gut microbial composition and functions are strongly influenced by diet.
• This complex intestinal ecosystem affects metabolic balance by modulating energy absorption, gut motility, appetite, glucose and lipid metabolism, and hepatic fat storage.
• Imbalance between gut microbes and the host's immune system could lead to bacterial fragments entering the bloodstream, resulting in systemic inflammation and insulin resistance.
• Weight loss from diet or bariatric surgery can significantly alter gut microbial composition, which may influence the effectiveness of these treatments.
• Manipulation of gut microbiota with prebiotics or probiotics could potentially reduce low-grade intestinal inflammation and improve gut barrier function.

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