Targeting the gut microbiota with resveratrol: a demonstration of novel evidence for the management of hepatic steatosis

Resveratrol treatment resulted in marked decreases in body weight and liver steatosis in high-fat diet-fed mice.

• Resveratrol is associated with improved insulin resistance in high-fat diet-fed mice.
• Treatment with resveratrol may enhance gut barrier function by repairing intestinal tissue and increasing protective factors.
• Resveratrol supplementation could alter gut microbiota composition, decreasing harmful bacteria and increasing beneficial bacteria that produce short-chain fatty acids.
• Transplantation of modified gut microbiota from resveratrol-treated mice into high-fat diet-fed mice led to reductions in body weight, liver fat, and low-grade inflammation.
• These findings suggest that resveratrol may serve as a dietary intervention to improve the intestinal environment and combat nonalcoholic fatty liver disease.

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