BMC microbiologyJul 17, 2025

Links between gut bacteria and blood metabolism in people with nerve-related rosacea

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Mar 16, 2026

Abstract

Analysis revealed 56 differentially abundant metabolites in patients with neurogenic rosacea compared to healthy controls.

Patients with neurogenic rosacea exhibited significant dysbiosis in gut microbiota.
Increased abundances of Lachnospiraceae, Veillonellaceae, and Clostridiaceae were observed, while Prevotellaceae and Bifidobacteriaceae decreased.
Strong positive correlations were found between specific serum metabolites and gut microbial taxa.
Notable correlations included 3,4-dihydroxyphenylacetic acid with Bifidobacterium (r = 0.7307) and Lactobacillus (r = 0.6898).
These findings indicate complex interactions between metabolic dysregulation and gut microbial imbalances in neurogenic rosacea.

Simplified

This study aimed to investigate the association between serum metabolomic profiles and the gut microbiota in patients with neurogenic rosacea. We analyzed the serum metabolites and gut microbial composition in 20 patients with neurogenic rosacea and 14 healthy controls. Metabolomic analysis identified 56 differentially abundant metabolites (DAMs), with benzene and substituted derivatives, carboxylic acids and derivatives, and organophosphates being among the most enriched categories. Gut microbiota analysis revealed significant dysbiosis in patients with neurogenic rosacea, characterized by an increased abundance of Lachnospiraceae, Veillonellaceae, and Clostridiaceae, and decreased levels of Prevotellaceae and Bifidobacteriaceae. Spearman's correlation analysis demonstrated significant relationships between specific serum metabolites and gut microbial taxa, including strong positive correlations between 3,4-dihydroxyphenylacetic acid and both Bifidobacterium (r = 0.7307, padj = 9.25e-07) and Lactobacillus (r = 0.6898, padj = 6.39e-06). These findings highlight the complex interactions between metabolic dysregulation and gut microbial imbalances in neurogenic rosacea, suggesting a potential role for the gut-skin axis in its pathophysiology. This study paves the way for future therapeutic strategies targeting both metabolic and microbial dysbiosis to manage neurogenic rosacea.

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Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. The protocol was reviewed and approved by the Ethics Committee of Southwest Hospital, First Affiliated Hospital of Army Medical University (Approval No. (A)KY2023192). Written informed consent was obtained from all participants prior to their enrollment in the study. Participants were informed of their right to withdraw from the study at any time without consequences. All data were anonymized to protect participant confidentiality. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

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Links between gut bacteria and blood metabolism in people with nerve-related rosacea

Abstract

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