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Gut microbiota regulates stress responsivity via the circadian system
Gut bacteria influence stress responses through the body’s internal clock
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Abstract
Microbial depletion disrupts brain activity and hormone patterns, leading to hyper-activation of the stress response system.
- The gut microbiota regulates the rhythm of the hypothalamic-pituitary-adrenal (HPA) axis.
- Depleting gut microbes alters brain activity related to stress in the hippocampus and amygdala.
- This alteration is linked to disrupted daily patterns of glucocorticoid secretion.
- Microbial changes can lead to specific impairments in stress responses based on the time of day.
- Transplanting gut microbes demonstrates that specific bacterial strains, like L. reuteri, may influence hormone release.
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