Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Tryptophan metabolism is influenced by gut microbiota and impacts human health.

• Tryptophan (Trp) is an essential aromatic amino acid involved in various metabolic pathways.
• The gut microbiota directly or indirectly regulates the metabolism of Trp into serotonin, kynurenine, and indole derivatives.
• These metabolic pathways play a central role in the interaction between gut microbes and the host.
• Understanding the balance between these pathways may enhance insight into disease mechanisms.
• Research on Trp metabolism could lead to new therapeutic approaches for human diseases.

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