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Gut physiology and environment explain variations in human gut microbiome composition and metabolism
How Gut Function and Surroundings Explain Differences in Human Gut Microbes and Their Activity
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Abstract
Substantial daily fluctuations in and metabolism were observed in 61 healthy adults over 9 days.
- Intra-individual variations in the gut microbiome and metabolism are linked to changes in stool moisture and faecal pH.
- Inter-individual variations are associated with differences in whole-gut and segmental transit times and pH levels.
- Metabolites from microbial carbohydrate fermentation tend to correlate negatively with gut passage time and pH.
- Positive correlations were found between proteolytic metabolites, breath methane, and transit times.
- Associations exist between segmental /pH and metabolites derived from coffee, diet, host, and microbes.
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Key numbers
23.3 h
Median Whole-Gut
Measured using SmartPills in 50 participants.
2.2–24%
Intra-individual Variation in Stool Moisture
Observed over 9 days in healthy adults.
0.3–8.1%
Intra-individual Variation in Faecal pH
Measured across the study period.