Trials

Gut-related effects on nerve signals linked to high blood pressure in a controlled clinical trial

Updated

Abstract

Hypertension affects 1 in 3 Australian adults, with over 50% struggling to control their blood pressure.

  • Diet significantly impacts cardiovascular health, with high-fiber intake linked to lower blood pressure.
  • Short-chain fatty acids (SCFAs) are produced from fiber fermentation and may play a role in managing blood pressure.
  • A previous clinical trial indicated that high amylose maize starch enriched with acetate and butyrate (HAMSA/B) reduced blood pressure in hypertensive patients.
  • The exact mechanism of action for SCFAs in blood pressure regulation is not fully understood.
  • SCFAs may affect blood pressure by reducing muscle sympathetic nerve activity, which is elevated in hypertension.

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