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Separating the Hallucinogenic and Brain-Change Effects of Psilocybin
Updated
Abstract
Essence
Psilocybin-induced neuroplasticity appears separable from hallucination through 5-HT2A receptors in cortical layer 5 pyramidal neurons.
Evidence
This in vivo longitudinal imaging and cell-type-specific manipulation study examined synapse formation, maturation, elimination, and 5-HT2A receptor expression in L5 pyramidal neurons.
Caveat
The abstract does not specify the species, sample size, behavioral measures, or durability of the observed synaptic effects.
Simplified
Psychedelic Science