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Identification of HDA15-PIF1 as a key repression module directing the transcriptional network of seed germination in the dark
A protein pair that controls gene activity to stop seeds from sprouting in the dark
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Abstract
Histone deacetylase15 () negatively regulates PHYB-dependent seed germination.
- Overexpression of HDA15 in Arabidopsis inhibits seed germination associated with phytochrome B (PHYB).
- Loss of function of HDA15 increases PHYB-dependent seed germination.
- HDA15 acts downstream of PHYB and represses seed germination through phytochrome-interacting factor1 ().
- HDA15 interacts with PIF1 in both laboratory and living plant conditions.
- HDA15 and PIF1 co-regulate light-responsive genes involved in hormonal signaling and cellular processes during germination.
- PIF1 recruits HDA15 to specific gene regions, reducing histone H3 acetylation and repressing gene expression.
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Key numbers
higher germination rates
Germination Rate Increase
Loss of function leads to increased germination rates in PHYB-inactivated conditions.
267 genes
Co-regulated Genes
and co-repress 267 genes in imbibed seeds under FR conditions.
decreased histone H3 acetylation
Histone Acetylation Levels
and decrease histone H3 acetylation levels of target genes.