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Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study
Heart failure, chronic kidney disease, and death risk in type 2 diabetes: Findings from a large international study
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Abstract
Of 1,177,896 patients with type 2 diabetes, 772,336 (66%) were free from cardiovascular or renal disease (CVRD) at the start of the study.
- Over a mean follow-up of 4.5 years, 137,081 patients (18%) developed their first manifestation of CVRD.
- The most common initial manifestations were chronic kidney disease (36%), heart failure (24%), stroke (16%), myocardial infarction (14%), and peripheral artery disease (10%).
- Heart failure and chronic kidney disease were linked to significantly higher risks of cardiovascular and all-cause mortality.
- The hazard ratios for heart failure and chronic kidney disease were 2.02 and 2.05, respectively, indicating more than double the risk compared to those free of CVRD.
- The combination of heart failure and chronic kidney disease presented the highest mortality risks, with hazard ratios of 3.91 and 3.14 for cardiovascular and all-cause mortality, respectively.
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Key numbers
2.02
Increase in Mortality Risk (Heart Failure)
Hazard ratio for all-cause mortality in patients with heart failure vs. CVRD-free status.
2.05
Increase in Mortality Risk (Chronic Kidney Disease)
Hazard ratio for cardiovascular mortality in patients with chronic kidney disease vs. CVRD-free status.
137081 of 772336
Prevalence of Cardiorenal Disease Manifestation
Number of patients developing first CVRD manifestation out of those initially CVRD-free.