Heart failure with preserved ejection fraction and metabolic dysfunction-associated steatotic liver disease: Twin challenges, one metabolic solution

Mar 10, 2025World journal of cardiology

Heart failure with normal pumping and fatty liver disease linked to metabolism: Two problems, one metabolic approach

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Abstract

Heart failure with preserved ejection fraction (HFpEF) has become the most common type of heart failure.

  • HFpEF is primarily associated with chronic low-grade inflammation and metabolic disorders.
  • The coexistence of HFpEF and metabolic dysfunction-associated steatotic liver disease (MASLD) complicates clinical management due to overlapping metabolic issues.
  • Sodium-glucose cotransporter 2 inhibitors have demonstrated potential benefits in treating both HFpEF and MASLD.
  • Glucagon-like peptide-1 receptor agonists are under investigation for their possible advantages in managing MASLD.
  • A comprehensive approach that integrates metabolic and cardiovascular care may be crucial for improving patient outcomes.

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