Heat stress triggers selective removal of cell parts in yeast

Heat shock leads to the targeted degradation of protein aggregates in Saccharomyces cerevisiae.

• Autophagy serves as a protective mechanism for recovery and viability following heat stress.
• Ubiquitinated protein aggregates are specifically degraded in response to heat shock.
• The macroaggrephagy receptor Cue5 mediates the degradation process triggered by heat stress.
• Heat stress also promotes the turnover of the aggrephagy receptor Cct2 and the polyglutamine repeats of the huntingtin protein.
• Cct2 and polyQ-HTT degradation occurs independently of traditional autophagy pathways.

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