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Abstract
An integrated lipidomics and metabolomics approach identified metabolic changes associated with H. pylori infection along the gut-brain axis.
- H. pylori infection in gastric epithelial cells was linked to changes in the secretome that influenced neuronal cells.
- Significantly altered metabolites and lipid species were identified through comprehensive molecular profiling.
- Dysregulated metabolic pathways were uncovered through statistical and pathway enrichment analyses.
- Network-based interaction analysis revealed key molecular hubs that may connect H. pylori infection to neuronal metabolic dysfunction.
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