Hepatobiliary and pancreatic: Multi‐donor fecal microbiota transplantation attenuated high‐fat diet‐induced hepatic steatosis in mice by remodeling the gut microbiota

Fecal microbiota from healthy donors significantly improved liver fat accumulation in mice fed a high-fat diet.

• Fecal samples from NAFLD patients exhibited significantly lower microbial diversity compared to healthy controls.
• Multi-donor fecal microbiota transplantation (MD-FMT) reduced liver fat accumulation and body weight in high-fat diet-fed mice.
• MD-FMT significantly improved serum and liver biochemical indices in treated mice.
• MD-FMT decreased the relative expression of inflammatory markers IL-1β, IL-6, TNF-α, and IFN-γ in the liver of treated mice.
• Intestinal barrier components and serum lipopolysaccharide levels improved following MD-FMT intervention.
• MD-FMT reversed high-fat diet-induced gut dysbiosis and increased levels of beneficial bacteria such as Blautia and Akkermansia.

AI simplified