Liver cell aging linked to metabolic fat-related liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with high morbidity and disease burden.

• Cellular senescence has been identified as a core mechanism driving the onset and progression of MASLD.
• Hepatocytes can enter a senescent state due to metabolic stress.
• Senescent hepatocytes secrete pro-inflammatory and profibrotic factors that exacerbate hepatic inflammation.
• The activation of hepatic stellate cells by these factors may lead to pathological fibrosis.
• Key molecular pathways of hepatocyte senescence impact the progression of MASLD.

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