Full text is available at the source.
Abstract
Hesperidin, a bioactive flavonoid found in citrus fruits, has potential multidimensional health benefits.
- Hesperidin is associated with anti-inflammatory, antioxidative, cardiovascular, neuroprotective, and metabolic-regulatory effects.
- Poor bioavailability and variations in clinical efficacy may limit the therapeutic use of hesperidin.
- Nanotechnology developments, such as nano-encapsulation and phytosome-based delivery systems, could improve the absorption and specific delivery of hesperidin.
- Emerging data highlight hesperidin's role in influencing the gut-brain axis and gut microbiome.
- Hesperidin may offer beneficial effects against chronic low-grade inflammation and metabolic and neurodegenerative diseases.
- Further phase 2 or 3 clinical trials are necessary to determine optimal dosing, long-term safety, and potential synergies with other bioactive compounds.
Simplified