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Abstract
The homologous mRNA/LNP regimen induced a strong humoral response with a more balanced IgG1:IgG2c ratio.
- Heterologous vaccinations may lead to immune responses reflective of the initial vaccine received.
- Robust cellular responses in heterologous regimens were observed only when primed with mRNA/LNP vaccines.
- The homologous protein subunit regimen resulted in a dominating IgG1 response with strong CD4T cell activation only.
- Different vaccination regimens could induce varying immunological profiles, potentially affecting long-term immunity.
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