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Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses
Strong and balanced immune responses from a SARS-CoV-2 protein booster with special particles after an mRNA vaccine
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Abstract
The homologous mRNA/LNP regimen induced a strong humoral response with a more balanced IgG1:IgG2c ratio.
- Heterologous vaccinations may lead to immune responses reflective of the initial vaccine received.
- Robust cellular responses in heterologous regimens were observed only when primed with mRNA/LNP vaccines.
- The homologous protein subunit regimen resulted in a dominating IgG1 response with strong CD4T cell activation only.
- Different vaccination regimens could induce varying immunological profiles, potentially affecting long-term immunity.
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