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Abstract
A high dietary inflammatory index (DII) score is associated with proinflammatory properties of a Western diet.
- Dietary habits can influence gene expression related to obesity, diabetes, cardiovascular disease, cancer, and neurodegenerative diseases.
- A Western diet disrupts the gut microbiome, creating an environment linked to low-grade systemic inflammation and oxidative changes.
- Increased intestinal permeability and compromised blood-brain barrier integrity may contribute to the development of diet-dependent neurodegenerative diseases.
- The gut-brain axis may mediate proinflammatory signaling influenced by the inflammatory potential of the diet.
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