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A high-fat diet and high-fat and high-cholesterol diet may affect glucose and lipid metabolism differentially through gut microbiota in mice
High-fat and high-fat plus cholesterol diets may differently affect sugar and fat metabolism through gut bacteria in mice
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Abstract
A high-fat and high-cholesterol diet significantly increased liver weight and fat infiltration in mice after 12 weeks.
- The high-fat diet (HFD) led to increased body weight and visceral fat accumulation, along with reduced oral glucose tolerance.
- The high-fat and high-cholesterol diet (HFHCD) resulted in higher liver triglycerides and total cholesterol compared to both the normal diet and the HFD.
- Serum cholesterol levels, including high-density and low-density lipoprotein cholesterol, were elevated in mice on the HFHCD compared to those on the normal diet and HFD.
- The HFHCD significantly decreased the diversity of fecal bacteria more than the HFD did, indicating a notable change in gut microbiota.
- Distinct differences in the composition of fecal bacteria were observed between the three dietary groups.
- Cecal short-chain fatty acids were significantly lower in mice fed either the HFD or HFHCD after 12 weeks.
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