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High Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment
High Blood Sugar May Cause Immune Cell Aging by Damaging Energy Factories and Blocking Their Cleanup Process
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Abstract
High glucose increased markers of macrophage senescence, including SA-β-Gal staining and cytokine secretion.
- Chronic hyperglycemia is linked to accelerated immune aging and diabetic complications.
- Mitochondrial dysfunction was indicated by a decrease in mitochondrial membrane potential and increased mitochondrial reactive oxygen species.
- Impaired mitophagy was characterized by PINK1 accumulation and reduced Parkin recruitment.
- Treatment with antioxidants or metformin restored mitochondrial function and reduced senescence markers.
- Mitochondrial dysfunction and impaired mitophagy may be key factors in high glucose-induced macrophage aging.
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