High-Intensity Interval Training May Reduce Heart Cell Stress and Repair Problems in Healthy Rats After Taking Methylphenidate and Alcohol

High-intensity interval training (HIIT) may influence cardiac complications associated with the concurrent use of methylphenidate (MPD) and ethanol (ET).

• Concurrent consumption of MPD and ET is common among young individuals and those with ADHD.
• The study focused on the effects of HIIT on oxidative stress linked to MPD and ET use.
• Mitochondrial processes such as fission, fusion, and mitophagy were examined in relation to cardiac health.
• Potential cardiac complications may arise from the combined effects of MPD and ET.

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