Archives of orthopaedic and trauma surgeryMar 21, 2016

Are people with hip or knee replacement at higher risk of falls and fractures? Data from the Osteoarthritis Initiative

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 31, 2026

Abstract

Participants who underwent total hip arthroplasty (THA) had a 65% lower chance of experiencing a fracture in the first 12 months post-surgery compared to those who did not have the procedure.

There was no significant difference in falls between those who had total knee arthroplasty (TKA) or THA and a non-arthroplasty group.
The odds of falling after THA were 0.90, while for TKA, it was 0.95, indicating similar fall risks across groups.
No statistical difference in fracture risk was observed between TKA recipients and the non-arthroplasty cohort.
Participants who underwent THA showed a significantly lower rate of fractures compared to the non-THA group.
The analysis utilized data from the US Osteoarthritis Initiative, involving 104 THA, 165 TKA, and 4631 non-arthroplasty participants.

Simplified

INTRODUCTION: Falls are a major challenge for older people and are a significant source of mortality and morbidity. There has been uncertainty as to whether people with total hip (THA) or knee (TKA) arthroplasty have a greater risk of falls and associated fractures. This analysis was to explore this question with a large community dataset.

MATERIALS AND METHODS: Data from all people enroled onto the US Osteoarthritis Initiative programme who had undergone a THA (n = 104) or TKA (n = 165), within a 12-month period, were compared to those who had not undergone an arthroplasty (n = 4631). Data were collected on: the number of participants who reported a fall within a 12-month period; the frequency of falls in this period; and whether a fracture was sustained during this period. Odd ratios were calculated for the probability of experiencing a fall or fracture between the groups.

RESULTS: There was no statistical difference in falls between people following THA (OR 0.90; 95 % CI 0.58-1.41) or TKA (OR 0.95; 0.67-1.35) compared to a non-arthroplasty cohort. Whilst there was no statistical difference in fracture risk between people following TKA compared to non-arthroplasty individuals (OR 1.25; 95 % CI 0.57-2.70), those who underwent THA had a 65 % lower chance of experiencing a fracture in the initial 12 post-operative months compared to the non-THA cohort (OR 0.35; 95 % CI 0.19-0.65; p < 0.01).

CONCLUSIONS: There appears a lower chance of experiencing a fracture for people following THA compared to those who have not.

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Are people with hip or knee replacement at higher risk of falls and fractures? Data from the Osteoarthritis Initiative

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