Current opinion in HIV and AIDS

New insights into how HIV affects the nervous system beyond the brain

Updated

Abstract

Neurocognitive disorders affect a subset of people with HIV despite long-term viral suppression with antiretroviral therapy (ART).

  • Persistent neuropathology may occur in people with HIV due to mechanisms not fully understood.
  • Current treatments for neuropathology in HIV are largely nonspecific and vary by patient.
  • Emerging evidence suggests a significant role of the gut-brain axis in HIV-associated neuropathology.

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