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Abstract
Dry mass measurements of microglia may serve as a potential indicator of cellular senescence and impaired phagocytosis.
- Senescent microglia show significant molecular changes linked to decreased ability to clear amyloid-β.
- Cellular dry mass and morphological features are identified as sensitive indicators of microglial senescence.
- Induction of microglial senescence was achieved using optimized hydrogen peroxide treatment.
- A strong correlation was found between dry mass and the decline in phagocytic capacity in senescent microglia.
- Aβ-treated senescent microglia displayed lower dry mass and smaller cell size, alongside larger nuclear size compared to controls.
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