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Bridging two worlds: Host Microbiota crosstalk in health and dysregulation
Communication between the body and gut bacteria in health and disease
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Abstract
The gut microbiota significantly influences immune processes and intestinal barrier integrity through microbial metabolites.
- Microbial compounds, such as and tryptophan metabolites, regulate immune responses and maintain intestinal barrier function.
- Disruption in microbiota composition can lead to , which is associated with altered host interactions and impaired immune regulation.
- Dysbiosis may promote inflammation by activating specific signaling pathways and gene transcription involved in pro-inflammatory responses.
- The gut microbiota is linked to various disorders, including gastrointestinal, metabolic, and neurological conditions.
- Therapeutic interventions may be necessary to restore microbial balance and support overall physiological functions.
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