[Effects of huannao yicong recipe extract on the learning and memory and related factors of Abeta generation in the brain of APP transgenic mice].

In a study involving APP transgenic mice, significant reductions in the expression of amyloid precursor protein and related proteins were observed with early application of Huannao Yicong Recipe extract.

• The Morris water maze test indicated a decline in learning and memory ability in 7-month-old APP transgenic mice compared to normal control mice.
• All treatment groups, including those receiving Huannao Yicong Recipe extract, showed improved performance in the Morris water maze compared to the model group.
• Significant increases in the levels of amyloid precursor protein, beta-site APP-cleaving enzyme 1, presenilin-1, and beta amyloid protein were noted in the hippocampus of untreated transgenic mice.
• Treatment with Huannao Yicong Recipe extract led to significant reductions in the levels of these proteins in the hippocampus compared to the untreated model group.
• These findings suggest that HNYCR extract may mitigate the pathological processes associated with Alzheimer's disease in APP transgenic mice.

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