Human Apolipoprotein E Redistributes Fibrillar Amyloid Deposition in Tg-SwDI Mice

Both human ApoE3 and ApoE4 proteins led to a strong reduction in cerebral microvascular amyloid in transgenic mice.

• Human ApoE genotype is associated with changes in the accumulation of amyloid in the brain, specifically shifting from microvascular to parenchymal forms.
• Transgenic mice carrying human ApoE3 or ApoE4 showed extensive fibrillar parenchymal plaque amyloid alongside reduced microvascular amyloid.
• There was no significant difference in total levels of amyloid-beta peptides or in their soluble and insoluble forms between the different ApoE backgrounds.
• Strong colocalization of all ApoE proteins with fibrillar amyloid deposits was observed in the mice.
• The changes in amyloid distribution corresponded with a shift in the activation of microglia, suggesting a response to the spatial accumulation of amyloid.

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