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Abstract
A modular human forebrain organoid platform integrates human stem cell-derived microglia and CD8+ T cells to study Alzheimer's disease pathology.
- Microglia are involved in clearing amyloid-beta and promoting neuron maturation.
- Microglia also activate inflammation and recruit CD8+ T cells through specific signaling pathways.
- This recruitment occurs via CCL4/5 signaling interacting with CCR1/5 and CXCR3 receptors.
- Blocking CCR5 or CXCR3 can prevent T cell recruitment and influence autophagy in microglia.
- The organoid system offers a new approach for exploring neuron-immune interactions and testing potential therapies.
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