Full text is available at the source.
Humulus lupulus L.: Evaluation of Phytochemical Profile and Activation of Bitter Taste Receptors to Regulate Appetite and Satiety in Intestinal Secretin Tumor Cell Line (STC‐1 Cells)
Humulus lupulus (Hop): Plant Compounds and Activation of Bitter Taste Receptors to Influence Appetite and Fullness in Intestinal Tumor Cells
AI simplified
Abstract
The hop extract is a rich source of bitter compounds that may stimulate hormone secretion to reduce hunger.
- Bitter compounds in the hop extract primarily include α- and β-acids.
- Activation of bitter taste receptors (TAS2Rs) in the intestine could enhance the secretion of appetite-reducing hormones such as glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK).
- The extract may decrease levels of hunger-related hormones like ghrelin.
- The secretion of GLP-1 and CCK is associated with calcium signaling pathways activated by TAS2Rs.
- Inhibition of specific receptors and calcium channels reduces the hormone secretion response to the hop extract.
AI simplified