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Huntington’s chorea: emerging fields in therapeutics (Review)
New Developments in Treatments for Huntington's Disease
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Abstract
Huntington's disease (HD) is caused by CAG repeat expansions in the HTT gene, leading to mutant huntingtin protein that disrupts neuronal function.
- HD is characterized by motor dysfunction, cognitive decline, and psychiatric disturbances.
- Genetic, molecular, and environmental factors contribute to the pathogenesis of HD.
- Current management approaches include various emerging therapeutic strategies.
- Novel therapies such as RNA interference, antisense oligonucleotides, peptide inhibitors, and CRISPR/Cas9 gene editing may shift the focus towards disease-modifying interventions.
- Ongoing clinical and translational research is needed to develop a definitive cure.
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