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Hyaluronic acid-based three dimensional scaffold in combination with hyperbaric oxygen therapy promote diabetic wound healing
Three-dimensional hyaluronic acid scaffold combined with high-pressure oxygen may improve healing of diabetic wounds
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Abstract
Wound contraction was significantly accelerated in all treatment groups compared to controls, with the HAS+HBOT group showing the greatest improvement (p < 0.05).
- Enhanced fibroblast proliferation and increased blood vessel formation were observed in treated groups, especially in the HAS+HBOT group.
- Reduced neutrophil infiltration was noted in the treatment groups, indicating lower inflammation levels.
- Collagen content was significantly higher in treated wounds, as evidenced by increased hydroxyproline levels and trichrome staining.
- Elevated levels of VEGF and TGF-β were found in the HAS+HBOT group, along with decreased levels of TNF-α and IL-1β.
- Biomechanical testing revealed superior maximum force and energy absorption in the HAS+HBOT group compared to all other groups.
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