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Abstract
Impaired mitophagy in cancer cells is associated with elevated ROS and promotes tumor growth.
- Dysfunctional mitochondria accumulate in cancer cells due to impaired mitophagy.
- Increased levels of reactive oxygen species (ROS) are observed in these cells.
- Activation of pro-survival pathways is linked to the accumulation of dysfunctional mitochondria.
- ROCK2, a kinase that is overexpressed in cancer, negatively affects the process of mitophagy.
- Targeting ROCK2 may offer a potential therapeutic approach in cancer treatment.
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