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Abstract
This trial aims to investigate the individual and synergistic effects of HMB and 2-HOBA supplementation on healthspan-related outcomes in healthy older adults.
- Ageing is associated with declines in muscle mass, cognitive performance, cardiorespiratory fitness, and immune function.
- Nutritional interventions like HMB may help mitigate muscle atrophy, while 2-HOBA could reduce neuroinflammation.
- Chronic low-grade inflammation and oxidative stress are linked to anabolic resistance in ageing muscle.
- Reducing inflammation may enhance the muscle-building effects of HMB.
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