Journal of advanced researchOct 10, 2026

Hyodeoxycholic acid may help bone stem cells fight aging and abnormal fat buildup in postmenopausal osteoporosis through a specific cell cleanup pathway

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Oct 11, 2026

Abstract

Bile acids, such as hyodeoxycholic acid (HDCA), may play a role in postmenopausal osteoporosis (PMOP) linked to bone marrow stromal cell (BMSC) dysfunction.

Postmenopausal osteoporosis is associated with bone marrow stromal cell senescence and abnormal fat cell development.
A deficiency in 17β-estradiol (E2) is a primary trigger for these changes in BMSCs.
The specific metabolic pathways that connect E2 loss to BMSC dysfunction are currently unclear.
Hyodeoxycholic acid (HDCA) has not been previously examined for its potential impact on BMSC function in the context of PMOP.

Simplified

Postmenopausal osteoporosis (PMOP) is driven by bone marrow stromal cell (BMSC) senescence and aberrant adipogenesis, with 17β-estradiol (E2) deficiency as a primary trigger. However, the metabolic mediators linking systemic E2 loss to BMSC dysfunction remain undefined. Bile acids are established endogenous "metabolic rejuvenators," but the functional relevance of hyodeoxycholic acid (HDCA) to BMSC dysfunction and the development of PMOP has not been elucidated.

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Hyodeoxycholic acid may help bone stem cells fight aging and abnormal fat buildup in postmenopausal osteoporosis through a specific cell cleanup pathway

Abstract

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