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Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1/PMK-1/SKN-1 pathway
Hyperoside may extend lifespan in roundworms through a stress response pathway
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Abstract
Hyperoside treatment significantly extended the mean lifespan of wild-type C. elegans by up to 19.97%.
- Hyperoside improved healthspan by enhancing motility and reducing the accumulation of lipofuscin, an aging biomarker.
- The compound alleviated Parkinsonism symptoms in neurodegeneration models without affecting lipid balance or reproduction.
- Increased resistance to thermal, oxidative, and pathogenic stress was observed following hyperoside treatment.
- The lifespan-extending effects of hyperoside depend on the transcription factors DAF-16/FOXO, SKN-1/Nrf2, and HSF-1.
- Hyperoside promoted the nuclear movement of DAF-16 and SKN-1 and upregulated their downstream target genes.
- The beneficial effects are likely mediated through the SEK-1/PMK-1/SKN-1 pathway, which also activates HSF-1 to maintain proteostasis.
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