Hypertension in obstructive sleep apnea: risk and therapy

Jun 10, 2009Expert review of cardiovascular therapy

High Blood Pressure Risk and Treatment in Obstructive Sleep Apnea

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Abstract

Obstructive sleep apnea (OSA) is associated with a persistent elevation of blood pressure due to intermittent hypoxia.

  • Intermittent hypoxia in OSA contributes to increased sympathetic nervous system activity.
  • Oxidative stress and inflammation are heightened in individuals with OSA.
  • Endothelial dysfunction may result from the pathophysiological changes associated with OSA.
  • OSA is recognized as a significant risk factor for the development of hypertension.
  • Treatment of OSA using continuous positive airway pressure may improve hypertension control and reduce cardiovascular disease risk.

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