Full text is available at the source.
A hypothalamic circuit for circadian regulation of corticosterone secretion
A brain circuit controlling daily rhythms of stress hormone release
AI simplified
Abstract
In male mice, the daily surge of corticosteroid secretion is regulated by a neural circuit involving the suprachiasmatic nucleus and the dorsomedial hypothalamus.
- Corticosteroid secretion exhibits a strong circadian rhythm, starting several hours before the active period.
- Input from the suprachiasmatic nucleus to the subparaventricular zone is crucial for this rhythm.
- Both glutamatergic and GABAergic neurons in the dorsomedial nucleus of the hypothalamus are necessary for the corticosteroid surge.
- Glutamatergic neurons directly stimulate corticotrophin-releasing hormone neurons in the paraventricular nucleus.
- GABAergic neurons in the dorsomedial hypothalamus disinhibit these corticotrophin-releasing hormone neurons through another set of GABAergic neurons.
AI simplified