The ICU environment paradigm as a catalyst for better delirium models

Incorporating ICU-like environmental stressors into animal delirium models may enhance translational validity.

• Environmental stressors such as light, noise, and sleep disruption are proposed to improve animal models of delirium.
• The combination of these stressors with surgical or sepsis interventions may better replicate human ICU delirium.
• This approach supports the discovery of underlying mechanisms related to delirium.
• Circadian disruption is highlighted as a potentially valuable area for future research.

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