Trends in immunology

Understanding Immune System Aging One Cell at a Time

Updated

Abstract

Single-cell sequencing has revolutionized the understanding of immune aging by revealing significant changes in cellular composition and function.

  • High-resolution analysis through single-cell technologies has uncovered previously unrecognized diversity in immune cells as people age.
  • Emerging immune aging clocks provide new ways to measure and understand the aging process in the immune system.
  • Technical and analytical challenges exist, particularly in integrating data from different platforms and populations.
  • Decoding immune aging at the single-cell level is associated with potential advancements in early detection of immune decline.

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Funding

Competing interests

Declaration of interests The authors declare that they have no conflict of interest.
PubMed

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