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Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization
Genetic differences in immune cells linked to migraine for finding treatment targets
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Abstract
Twenty-five immune cell-specific genes are causally associated with migraine.
- Genes such as CDC42 and HAX1 are implicated across multiple immune cell types.
- Subtype-specific analyses indicate different gene effects in migraine with aura and without aura.
- Genetic correlation links identified genes to comorbid conditions like depression and gastrointestinal disorders.
- PheWAS analysis suggests few adverse associations for prioritized genes.
- Drug repurposing identified FDA-approved medications as potential migraine therapies.
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Key numbers
25
Identified
Causally associated immune cell-specific linked to migraine
55,116
Migraine cases
Migraine cases from the primary dataset
445,232
Controls
Controls from the primary dataset