StrokeSep 3, 2026

Blocking Immune Checkpoint B7-H3 May Change Early Brain Inflammation and Protect the Brain After Stroke

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Sep 4, 2026

Abstract

The effect of regulating B7-H3 after acute ischemic stroke remains uninvestigated.

B7-H3 is associated with immune checkpoint regulation in the context of acute ischemic stroke.
Its role may influence brain damage and neuroinflammation following a stroke.
Regulating B7-H3 could impact vascular integrity and host defense gene regulation.
The study evaluates potential outcomes related to functional recovery after a stroke.

Simplified

The role of immune checkpoint B7-H3 in acute ischemic stroke prognosis and poststroke immunosuppression remains uninvestigated, despite the clinical significance of immune checkpoints with inflammaging and poststroke infections. In this study, we investigated the effect of regulating cerebral induction of B7-H3 after acute ischemic stroke and evaluated its longitudinal impact on brain damage, neuroinflammation, vascular integrity, host defense gene regulation, and functional outcomes.

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Blocking Immune Checkpoint B7-H3 May Change Early Brain Inflammation and Protect the Brain After Stroke

Abstract

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