Immune control and tumor environment in cancer treatments targeting PD-1/PDL-1 and CTLA-4: A research overview

A total of 4,778 publications were reviewed, revealing a significant increase in research on tumor immune evasion from 1999 to 2022.

• Bladder cancer was identified as a particularly prominent focus in the literature on immune evasion.
• China, the USA, and Japan were the leading countries contributing to this body of research.
• Major institutions included MD Anderson Cancer Center, Harvard Medical School, Fudan University, and Sun Yat Sen University.
• Key journals in the field featured Frontiers in Immunology, Cancers, and Frontiers in Oncology.
• Ehen LP and Wang W were noted as prolific authors, while Topalian SL was one of the most cited figures.
• Current research trends are increasingly addressing challenges such as immunotherapy resistance and the complex signaling pathways involved.

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