How the Immune System Monitors Aging Cells in Older Age and Illness

Senescent cells may accumulate in tissues due to compromised immune-mediated elimination with age.

• The immune system can target senescent cells through various components, including natural killer cells and macrophages.
• Age-related decline in immune function is associated with increased accumulation of senescent cells.
• Senescent cells possess intrinsic properties that may allow them to evade immune surveillance.
• Immune cells themselves can undergo senescence, which may impair their ability to detect and eliminate senescent and cancerous cells.
• Emerging therapeutic strategies aim to enhance the immune system's ability to identify and eliminate senescent cells.

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