mRNA Vaccine Triggers New IgG Antibody Responses Even When Maternal Antibodies Are Present

Maternally derived antibodies may inhibit vaccine-specific immune responses in infants.

• Infants are at increased risk for severe disease from vaccine-preventable infections due to maternal antibodies.
• SARS-CoV-2 has led to a significant number of hospitalizations in infants under 3 months.
• No approved vaccine exists for children younger than 6 months.
• There is a need for effective immunization strategies in early life to reduce infant morbidity and mortality.
• A mouse model was established to explore the impact of maternal antibodies on responses to mRNA vaccination.

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