Design of a multi-part mRNA vaccine targeting the main types of hepatitis E virus that infect people

Hepatitis E virus (HEV) is linked to severe diseases in immunocompromised individuals and pregnant women.

• HEV is a major cause of acute and chronic hepatitis worldwide.
• Only one vaccine is licensed, and it is available in China and Pakistan.
• The lack of globally approved mRNA vaccines for HEV indicates a gap in vaccination options.
• There is a pressing need for the development of alternative vaccines against HEV.

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