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Abstract
Gut microbiota dysbiosis is associated with autoimmune pathogenesis through various mechanisms.
- Dysbiosis may lead to immune dysregulation and increased intestinal permeability.
- Mechanisms like depletion of short-chain fatty acids (SCFAs) and Th17/Treg imbalance are implicated in autoimmune disorders.
- Molecular mimicry and disrupted signaling pathways may also contribute to the development of autoimmune conditions.
- Interventions such as probiotics, prebiotics, SCFA supplementation, and fecal microbiota transplantation (FMT) could modulate immune responses.
- Clinical and preclinical evidence suggests that restoring gut microbiota may serve as a potential immunotherapeutic approach.
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