Immunopharmacology of senescence: targeting the senescence-associated secretory phenotype (SASP)—a mechanism-based review

Cellular senescence is a natural process where cells permanently stop dividing, playing a role in cancer prevention and tissue repair.

• Senescent cells release inflammatory factors that can lead to chronic inflammation and disrupt immune function.
• The interaction between the immune system and senescent cells influences whether these cells are cleared or become harmful.
• Immunopharmacology explores how drugs can modify immune responses to target the harmful effects of senescent cells.
• Recent research highlights potential therapies aimed at removing senescent cells or altering their secretions to mitigate health issues.
• Developing therapies that target the senescence-associated secretory phenotype (SASP) may help improve health and address age-related diseases.

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