Inflammopharmacology

Immune-related drugs targeting the harmful secretions from aging cells

Updated

Abstract

Cellular senescence is a natural process where cells permanently stop dividing, playing a role in cancer prevention and tissue repair.

  • Senescent cells release inflammatory factors that can lead to chronic inflammation and disrupt immune function.
  • The interaction between the immune system and senescent cells influences whether these cells are cleared or become harmful.
  • Immunopharmacology explores how drugs can modify immune responses to target the harmful effects of senescent cells.
  • Recent research highlights potential therapies aimed at removing senescent cells or altering their secretions to mitigate health issues.
  • Developing therapies that target the senescence-associated secretory phenotype (SASP) may help improve health and address age-related diseases.

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Full Text

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Funding

Competing interests

Declarations. Conflict of interest: The authors declare no conflicts of interest. Ethics approval and consent to participate: This manuscript is a review. Hence, no experiments in animals or humans are included in this study, so ethical approval and consent are not required. Clinical trial number: The manuscript is a review article (not a part of Clinical trial); hence, no clinical trial number is applicable. Consent for publication: This manuscript does not contain any personal data. Hence, no consent is required. Availability of data and materials: Data sharing does not apply to this article as no data sets were generated or analyzed during the current study.
PubMed

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