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Abstract
Colorectal cancer (CRC) is associated with higher incidence and lethality in elderly individuals due to factors related to immunosenescence.
- Immunosenescence may contribute to the initiation, progression, and resistance to treatment of CRC.
- Molecular processes such as telomere shortening, impaired DNA repair, and oxidative stress are interconnected and may lead to immunosenescence.
- Disruptions in immune balance can promote chronic inflammation, which is linked to CRC development.
- Functional changes in immune cells, including macrophages and T lymphocytes, may facilitate immune evasion in CRC.
- The senescence-associated secretory phenotype (SASP) could influence the CRC microenvironment through inflammatory signals.
- Factors like gut microbiota imbalance and intestinal barrier dysfunction may accelerate immune aging and contribute to tumor development.
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