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Immunosenescence in multiple sclerosis: New insights and clinical implications
Aging of the Immune System in Multiple Sclerosis: New Understandings and Treatment Considerations
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Abstract
Evidence suggests premature aging of the immune system in multiple sclerosis (MS) patients.
- Changes in T cell function may indicate early cellular aging in younger MS patients.
- Reduced numbers of naïve lymphocytes could contribute to impaired immune responses in MS.
- An increase in proinflammatory CD28- T cells may be linked to the aging process in MS.
- Younger MS patients may exhibit an 'aged' phenotype in CD8+ T cells.
- The impact of immunosenescence may influence the effectiveness and safety of disease-modifying therapies in MS.
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